[09/04 1:34 PM] Pankaj Chhayani dr ndyad:  @ Ojha sir, pls sir discuss about Parkinson disease..11 April is world Parkinson disease.. We have many patients of Parkinson , and one pt of PSP that mimick Parkinson disease... What we can do in PSP..🙏 [09/04 1:34 PM] Pankaj Chhayani dr ndyad:  Is there any relationship between dhatuxaya and tremors? Or dopamine receptors failure and hypokinesia? [09/04 3:24 PM] satyendra ojha sir:  Since Parkinson's disease is neurodegenerative disease , so we have to think dhaatukshaya janya vaata prakopa.. The failure of dopamine receptors or deficiency of dopamine neurotransmitter is main reason for clinical features , but due to dopamine deficiency , the exaggerated acetylcholine also play roles in pathophysiology of features like tremors , therefore , anticholinergic & antihistamine like trihexiphenydil is found effective , however levodopa , dopamine agonist , with carbidopa is first choice.. The issue is first pass meta