1. Description of ‘Vyapad’ is the best to understand the reverse pathogenesis when desired action is not performed by body as a response to drugs induced. 2. Five fold description mentioned above, is sufficient to understand action of final triggering Nidan or cause that finally be responsible for the mechanism of Dosha-dooshya-sammoorchhana or pathogenesis viz Jivadan as a result of Teekshna drug in alpa-dosha along with Mridukoshthi. 3. Pre existing Dosha-dooshya condition as well as body response may be inferred As per the presentation of signs and symptoms either acute, subacute or chronic e..g. Parikartika or Jivadan. 4. A physician should be able to make hypothesis / identify the said pre-existing Dosha-sthiti as per the basic dash-vidh-parixa etc, and illustrated concept of ‘Vyapad’ must be helpful to understand that. 5. This will not only meaningful to assess the severity of clinical presentation but also in identifyi